Synthesis and Biological Evaluation of Novel 2-(5-(butylamino)- 1,3,4-thiadiazol-2- ylthio)-N-(4-(4-bromophenyl) thiazol-2-yl) Acetamide as Potential Anti-Cancer Drug”

Abstract

During the last two decades, tetrabutylammonium bromide (TBAB) has gained significant attention as an efficient metal-free homogeneous phase-transfer catalyst [1]. TBAB is an environmentally benign, non-volatile, non-corrosive, non-flammable, low-cost, commercially available ammonium salt with high chemical stability [2]. It has been successfully used in the liquid–liquid or solid–liquid phase-transfer alkylation of the NH groups of aromatic amine[3], amides[4], lactams[5], sulfonamides[6] and other heterocyclic nitrogen containing compounds[7].However, from literature survey, TBAB play limited. role either phase-transfer catalyst or catalyst but not having any other significance.